FLOATING TABLETS AND ITS POLYMERS
نویسندگان
چکیده
منابع مشابه
Gastric floating matrix tablets: design and optimization using combination of polymers.
The purpose of the present study was to develop an optimized gastric floating drug delivery system (GFDDS) containing domperidone as a model drug. Box-Behnken design was employed in formulating the GFDDS with three polymers: hydroxypropyl methylcellulose K4M (HPMC K4M) (X1), Carbopol 934P (X2) and sodium alginate (X3), as independent variables. Floating lag time (FLT), total floating time (TFT)...
متن کاملFormulation, Evaluation and Study of Effect of Hydrophilic Polymers on Release Rate of Cefixime Floating Tablets
Floating matrix tablets of cefixime trihydrate were developed to prolong gastric residence time and to increase drug absorption and hence bioavailability. Hydrophilic polymers viz. HPMC K4M and Xanthan gum were incorporated in varied proportions to develop floating matrix tablets of cefixime by direct compression method. Buoyancy was achieved by adding an effervescent mixture of sodium bicarbon...
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The various approaches to increase the gastric residence of dosage forms are: effervescent single/multiple unit dosage forms, non-effervescent single/multiple unit dosage forms, high density dosage forms, expandable systems, swelling systems, unfolding systems, and adhesionmucoadhesive systems. The floating drug delivery systems of this class contains one or more gel forming swellable cellulose...
متن کاملDevelopment and evaluation of regioselective bilayer floating tablets of Atenolol and Lovastatin for biphasic release profile
This study was performed to design bilayer regioselective floating tablets of atenolol and lovastatin to give immediate release of lovastatin and sustained release of atenolol. Bilayer floating tablets comprised two layers, i.e immediate release and controlled release layers. The immediate release layer comprised sodium starch glycollate as a super disintegrant and the sustained release layer c...
متن کاملPolymers in Fast Disintegrating Tablets – a Review
An oral solid dosage form should ideally disperse into the primary particles from which it was prepared. Tablets and capsules which need rapid disintegration, the inclusion of the right disintegrant is a prerequisite for optimal bioavailability. Superdisintegrants are used to improve the efficacy of solid dosage forms. This is achieved by decreasing the disintegration time which in turn enhance...
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ژورنال
عنوان ژورنال: Journal of Drug Delivery and Therapeutics
سال: 2018
ISSN: 2250-1177
DOI: 10.22270/jddt.v8i5-s.1928